HYPK

Across TCGA cell cohorts, HYPK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,886 significant associations in total. CNS shows the largest number of these associations.

The most reproducible HYPK-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Negative regulation of autophagy, and snoRNA guided rRNA pseudouridine synthesis. Each is linked with HYPK in more than 12 cancer types. Because this analysis shows association rather than direction, both HYPK-to-partner and partner-to-HYPK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by HYPK-low versus HYPK-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HYPK→partner) and Y-score (partner→HYPK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	-0.116	-1.408	.001	<.001	3	13
STOMACH	Negative regulation of autophagy →	-0.079	-1.543	.005	<.001	3	12
OVARY	snoRNA guided rRNA pseudouridine synthesis →	+0.125	+1.340	<.001	<.001	3	12
LIVER	Positive regulation of nucleocytoplasmic transport →	-0.090	-1.105	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of autophagy →	-0.060	-1.320	<.001	<.001	3	12
BONE	Regulation of RNA polymerase II transcription preinitiation complex assembly →	-0.171	-1.396	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,886 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by HYPK expression — BONE

Explore this box plot interactively →