HYOU1

Across TCGA pan-cancer cohorts, HYOU1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated HYOU1 data layer compared with 28 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher HYOU1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HYOU1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, HNSC, and UCEC are the cancer types where HYOU1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.604	0.975	<.001	24	view →
HNSC	DFS	Median	All	0.148	0.696	.004	24	view →
UCEC	DFS	Median	All	0.973	0.623	.006	10	view →
READ	OS	Median	II,III,IV	0.187	0.653	.030	6	view →
PRAD	DFS	Median	All	0.085	0.774	.006	6	view →
LUSC	DFS	Median	All	0.165	0.707	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

HYOU1–THYM (OS)

Open the THYM breakdown →