HYOU1

Across TCGA pan-cancer cohorts, HYOU1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of HYOU1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where HYOU1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types HYOU1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BLCA, and THCA are the cancer types where HYOU1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HYOU1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+1.136	<.001	12	view →
BLCA	Male	III,IV	+1.270	<.001	11	view →
THCA	All	IV	−2.679	<.001	10	view →
LIHC	Female	II,III,IV	+1.597	<.001	9	view →
LUAD	Male	III,IV	+1.578	<.001	9	view →
COAD	Male	II,III,IV	+0.676	<.001	9	view →
STAD	All	II,III,IV	+1.400	<.001	8	view →
LUSC	Male	II,III,IV	+1.212	<.001	8	view →
UCEC	All	All	+0.920	.002	6	view →
BRCA	All	All	+0.678	<.001	6	view →
KIRC	Female	III,IV	+0.518	.001	5	view →
CHOL	All	All	+1.472	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

HYOU1–HNSC

Open the HNSC breakdown →