HYOU1

Across TCGA patient cohorts, HYOU1 mutation is significantly associated with the RNA expression of many other genes, with 2,918 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HYOU1-associated genes across cancer lineages are RNU6-1138P, MIR200C, and RPL23AP4. Each is linked with HYOU1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HYOU1-to-partner and partner-to-HYOU1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1138P grouped by HYOU1-low versus HYOU1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYOU1→partner) and Y-score (partner→HYOU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1138P →	+0.627	+4.287	<.001	.008	3	3
BLCA	MIR200C →	+1.085	+3.593	.001	.009	3	3
READ	RPL23AP4 →	+0.171	+5.039	<.001	.008	3	2
READ	RPL32P19 →	+0.118	+5.653	<.001	.003	3	2
COAD	CNN2P10 →	+0.071	+3.516	<.001	.004	3	2
BLCA	MTCO3P39 →	+0.119	+5.018	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,918 associations by consensus.

RNU6-1138P by HYOU1 expression — LUSC

Explore this box plot interactively →