HYOU1

Across TCGA patient cohorts, HYOU1 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HYOU1-associated genes across cancer lineages are eIF4E, MEK1, and Annexin-1. Each is linked with HYOU1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HYOU1-to-partner and partner-to-HYOU1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by HYOU1-low versus HYOU1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYOU1→partner) and Y-score (partner→HYOU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.154	+1.459	.024	.012	3	3
UCEC	MEK1 →	+0.426	+2.247	<.001	.001	3	2
UCEC	Annexin-1 →	+0.345	+2.700	.043	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.695	+2.189	<.001	.001	3	2
UCEC	4E-BP1 →	+0.226	+2.252	.010	.005	3	2
UCEC	MSH2 →	-0.177	-1.973	.018	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

eIF4E by HYOU1 expression — UCEC

Explore this box plot interactively →