HYOU1

Across TCGA cell cohorts, HYOU1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,548 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HYOU1-associated GO terms across cancer lineages are Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway, Response to endoplasmic reticulum stress, and Endoplasmic reticulum to cytosol transport. Each is linked with HYOU1 in more than 17 cancer types. Because this analysis shows association rather than direction, both HYOU1-to-partner and partner-to-HYOU1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway grouped by HYOU1-low versus HYOU1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HYOU1→partner) and Y-score (partner→HYOU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway →	+0.238	+1.832	<.001	<.001	3	18
BLOOD_Myeloma	Response to endoplasmic reticulum stress →	+0.092	+0.992	.001	<.001	3	13
LUNG_NSCLC_LUSC	Endoplasmic reticulum to cytosol transport →	+0.139	+0.848	.004	.009	3	12
LUNG_NSCLC_LUSC	Retrograde protein transport, ER to cytosol →	+0.139	+0.848	.004	.009	3	12
LUNG_NSCLC_LUAD	Protein exit from endoplasmic reticulum →	+0.109	+0.758	<.001	<.001	3	12
BLOOD_Myeloma	ERAD pathway →	+0.078	+0.825	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,548 associations by consensus.

Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway by HYOU1 expression — OESOPHAGUS

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