HYOU1

Across TCGA cell cohorts, HYOU1 mutation is significantly associated with the RNA expression of many other genes, with 331 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HYOU1-associated genes across cancer lineages are GPR119, CLDN34, and AVP. Each is linked with HYOU1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HYOU1-to-partner and partner-to-HYOU1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR119 grouped by HYOU1-low versus HYOU1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYOU1→partner) and Y-score (partner→HYOU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR119 →	+0.227	+2.665	.002	.004	3	2
BLOOD_Myeloma	CLDN34 →	+0.043	+4.807	<.001	.006	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	C1orf87 →	+0.021	+4.867	.008	.009	3	1
BLOOD_Lymphoma	ART5 →	+0.122	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	DYNAP →	+0.102	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 331 associations by consensus.

GPR119 by HYOU1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →