Across TCGA patient cohorts, HYKK mutation is significantly associated with the RNA expression of many other genes, with 610 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HYKK-associated genes across cancer lineages are MIR1225, MRPS18BP2, and SUMO2P5. Each is linked with HYKK in more than 1 cancer types. Because this analysis shows association rather than direction, both HYKK-to-partner and partner-to-HYKK results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYKK→partner) and Y-score (partner→HYKK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR1225 →	+0.278	+3.027	<.001	.007	3	2
UCEC	MRPS18BP2 →	+0.130	+2.478	<.001	.001	3	2
SKCM	SUMO2P5 →	+0.075	+4.147	<.001	.008	3	2
UCEC	VDAC3P1 →	+0.369	+2.743	<.001	.003	3	1
UCEC	KRT8P49 →	+0.325	+2.700	<.001	.006	3	1
UCEC	IGKV1D-13 →	+1.632	+3.807	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 610 associations by consensus.

Exploration

HYKK survival (RNA) · tumor vs normal (RNA) · all HYKK data types