Across TCGA cell cohorts, HYKK mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible HYKK-associated genes across cancer lineages are OR1E1, LRIT2, and MEIKIN. Each is linked with HYKK in more than 1 cancer types. Because this analysis shows association rather than direction, both HYKK-to-partner and partner-to-HYKK results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYKK→partner) and Y-score (partner→HYKK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1E1 →	+0.647	+4.977	<.001	.007	3	1
SKIN	LRIT2 →	+0.029	+5.415	<.001	.004	3	1
SKIN	MEIKIN →	+0.019	+5.415	<.001	.004	3	1
CNS	SPATA8 →	+0.510	+4.315	<.001	.006	3	1
CNS	VN1R4 →	+0.073	+4.754	<.001	.005	3	1
LARGE_INTESTINE	BPY2 →	+0.030	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

HYKK survival (RNA) · tumor vs normal (RNA) · all HYKK data types