HYDIN2

Across TCGA pan-cancer cohorts, HYDIN2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HYDIN2 data layer compared with 1 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher HYDIN2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HYDIN2 expression acts as an unfavorable survival marker, although some lineages such as ACC and UCEC show a favorable association.

ACC, READ, and CESC are the cancer types where HYDIN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	II,III,IV	0.908	0.618	<.001	66	view →
READ	DFS	Tertile	All	0.269	0.735	.003	48	view →
CESC	DFS	Median	All	0.389	0.652	<.001	38	view →
UCEC	DFS	Quartile	IV	0.745	0.292	.008	36	view →
UCS	OS	Median	II,III,IV	0.599	0.243	.009	24	view →
KICH	DFS	Quartile	II,III,IV	0.442	0.884	.002	20	view →
KIRC	DFS	Median	All	0.820	0.900	.018	16	view →
HNSC	DFS	Median	IV	0.399	0.227	.004	15	view →
BLCA	DFS	Median	II,III,IV	0.566	0.657	.012	10	view →
SKCM	DFS	Quartile	IV	0.058	0.614	.006	9	view →
KIRP	DFS	Quartile	All	0.930	0.551	.005	9	view →
PCPG	OS	Median	All	0.632	1.000	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HYDIN2–ACC (OS)

Open the ACC breakdown →