HYDIN2

Across TCGA pan-cancer cohorts, HYDIN2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of HYDIN2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where HYDIN2 RNA is repressed in tumor relative to normal tissue. In most cancer types HYDIN2 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

KICH, UCEC, and BRCA are the cancer types where HYDIN2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HYDIN2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.160	<.001	8	view →
UCEC	All	III,IV	−0.355	<.001	6	view →
BRCA	All	III,IV	−0.196	.002	4	view →
HNSC	All	All	+0.038	.018	4	view →
COAD	Female	II,III,IV	−0.036	.004	4	view →
LIHC	All	All	+0.020	.008	3	view →
CHOL	All	All	+0.365	.003	2	view →
THCA	All	All	+0.156	.005	2	view →
STAD	All	All	−0.111	.016	2	view →
PRAD	All	All	−0.089	.003	2	view →
READ	All	All	−0.086	.009	2	view →
ESCA	Female	All	−0.136	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

HYDIN2–KICH

Open the KICH breakdown →