HYDIN

Across TCGA patient cohorts, HYDIN mutation is significantly associated with the total protein of many other genes, with 93 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HYDIN-associated genes across cancer lineages are Caveolin-1, NF-kB-p65_pS536, and PCNA. Each is linked with HYDIN in more than 4 cancer types. Because this analysis shows association rather than direction, both HYDIN-to-partner and partner-to-HYDIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by HYDIN-low versus HYDIN-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYDIN→partner) and Y-score (partner→HYDIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caveolin-1 →	-0.680	-2.584	.006	.008	3	5
STAD	NF-kB-p65_pS536 →	-0.370	-2.459	.012	.016	3	4
STAD	PCNA →	+0.221	+1.700	.021	.038	3	4
STAD	TFRC →	+0.446	+2.321	.031	.030	3	4
UCEC	4E-BP1 →	+0.292	+2.222	<.001	<.001	3	4
UCEC	PDCD4 →	-0.355	-1.584	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

Caveolin-1 by HYDIN expression — STAD

Explore this box plot interactively →