HYDIN

Across TCGA pan-cancer cohorts, HYDIN RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated HYDIN data layer compared with 11 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher HYDIN RNA is associated with better overall survival. In most high-consensus cancer types, elevated HYDIN expression acts as an unfavorable survival marker, although some lineages such as KIRP and ACC show a favorable association.

KIRP, ACC, and STAD are the cancer types where HYDIN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	II,III,IV	0.930	0.574	<.001	91	view →
ACC	OS	Tertile	II,III,IV	0.915	0.599	.001	74	view →
STAD	OS	Tertile	II,III,IV	0.365	0.552	.002	63	view →
UVM	DFS	Quartile	All	0.842	0.474	.001	62	view →
SCLC	OS	Tertile	II,III,IV	0.959	0.617	.005	56	view →
CESC	DFS	Median	All	0.397	0.611	<.001	34	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	27	view →
LGG	DFS	Quartile	All	0.770	0.882	.001	15	view →
LUSC	DFS	Median	All	0.317	0.433	.018	13	view →
BLCA	DFS	Quartile	All	0.543	0.665	.014	12	view →
KIRC	DFS	Quartile	II,III,IV	0.676	0.434	.006	12	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

HYDIN–KIRP (OS)

Open the KIRP breakdown →