HYDIN

Across TCGA cell cohorts, HYDIN mutation is significantly associated with the RNA expression of many other genes, with 1,213 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HYDIN-associated genes across cancer lineages are CEP135, CEP85, and DBR1. Each is linked with HYDIN in more than 2 cancer types. Because this analysis shows association rather than direction, both HYDIN-to-partner and partner-to-HYDIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP135 grouped by HYDIN-low versus HYDIN-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYDIN→partner) and Y-score (partner→HYDIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CEP135 →	+0.366	+1.949	.008	.002	3	3
LARGE_INTESTINE	CEP85 →	+0.554	+3.523	.006	<.001	3	3
LARGE_INTESTINE	DBR1 →	+0.574	+2.130	<.001	<.001	3	3
LARGE_INTESTINE	ANP32E →	+0.616	+2.130	.004	<.001	3	3
LARGE_INTESTINE	MMS22L →	+0.823	+1.807	<.001	.003	3	3
LARGE_INTESTINE	WDR43 →	+0.400	+3.652	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,213 associations by consensus.

CEP135 by HYDIN expression — SKIN

Explore this box plot interactively →