HYAL1

Across TCGA patient cohorts, HYAL1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,990 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible HYAL1-associated genes across cancer lineages are PCLO, ETHE1, and NME2P1. Each is linked with HYAL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HYAL1-to-partner and partner-to-HYAL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HYAL1 versus PCLO in GBM, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYAL1→partner) and Y-score (partner→HYAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PCLO →	-1.307	-0.514	.004	.007	3	2
HNSC	ETHE1 →	+0.557	+0.653	.007	.003	3	2
HNSC	NME2P1 →	-0.885	-0.573	.002	.002	3	2
LSCC	NPR1 →	+0.739	+0.411	<.001	<.001	3	2
LSCC	INMT →	+0.970	+0.361	.007	.004	2	3
LUAD	LINC02416 →	-0.807	-0.428	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,990 associations by consensus.

HYAL1 vs PCLO — GBM

Explore this scatter interactively →