HYAL1

Across TCGA pan-cancer cohorts, HYAL1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated HYAL1 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher HYAL1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HYAL1 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRC show a favorable association.

UVM, KIRC, and KIRP are the cancer types where HYAL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.808	0.394	<.001	112	view →
KIRC	DFS	Median	All	0.724	0.524	<.001	108	view →
KIRP	DFS	Tertile	All	0.968	0.830	<.001	66	view →
BLCA	DFS	Median	II,III,IV	0.448	0.567	.004	51	view →
COAD	DFS	Tertile	All	0.694	0.341	.009	45	view →
LUSC	OS	Tertile	III,IV	0.648	0.346	.003	35	view →
THCA	DFS	Tertile	All	0.949	0.856	.001	32	view →
SCLC	DFS	Tertile	II,III,IV	0.247	0.797	.016	27	view →
LUAD	DFS	Tertile	IV	0.472	0.943	.016	19	view →
DLBC	OS	Quartile	All	0.885	0.356	.014	13	view →
CHOL	DFS	Tertile	II,III,IV	0.184	0.611	.017	12	view →
STAD	DFS	Quartile	All	0.480	0.699	.009	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

HYAL1–UVM (OS)

Open the UVM breakdown →