HYAL1

Across TCGA patient cohorts, HYAL1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HYAL1-associated genes across cancer lineages are A-Raf_pS299, JNK_pT183_Y185, and Ku80. Each is linked with HYAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HYAL1-to-partner and partner-to-HYAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by HYAL1-low versus HYAL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYAL1→partner) and Y-score (partner→HYAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.168	-3.321	.002	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.224	-2.571	.004	.011	3	1
UCEC	Ku80 →	+0.351	+2.598	.001	.006	3	1
UCEC	MAPK_pT202_Y204 →	-0.594	-2.459	.006	.019	3	1
UCEC	MEK1_p_S217_S221 →	-0.316	-2.584	.013	.011	3	1
UCEC	MEK1 →	+0.562	+2.459	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

A-Raf_pS299 by HYAL1 expression — UCEC

Explore this box plot interactively →