HYAL1

Across TCGA cell cohorts, HYAL1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HYAL1-associated genes across cancer lineages are SERPINA7, NAT8B, and MGAT4D. Each is linked with HYAL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HYAL1-to-partner and partner-to-HYAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SERPINA7 grouped by HYAL1-low versus HYAL1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYAL1→partner) and Y-score (partner→HYAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SERPINA7 →	+0.012	+4.930	<.001	.008	3	1
BLOOD_Lymphoma	NAT8B →	+0.101	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	MGAT4D →	+0.020	+4.350	<.001	.005	3	1
SKIN	OR6C68 →	+0.031	+4.415	<.001	.007	3	1
BLOOD_Lymphoma	ABCG8 →	+0.022	+4.191	<.001	.007	1	1
SKIN	MUC21 →	+0.045	+4.523	<.001	.003	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

SERPINA7 by HYAL1 expression — SOFT_TISSUE

Explore this box plot interactively →