HYAL1

Across TCGA cell cohorts, HYAL1 mutation is significantly associated with the mutation status of many other genes, with 836 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HYAL1-associated genes across cancer lineages are TUBB1, WDR3, and SPATA32. Each is linked with HYAL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both HYAL1-to-partner and partner-to-HYAL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBB1 grouped by HYAL1-low versus HYAL1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HYAL1→partner) and Y-score (partner→HYAL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TUBB1 →	+4.053	+4.357	.001	.001	1	3
SKIN	WDR3 →	+3.638	+4.117	.002	.002	1	3
BLOOD_Lymphoma	SPATA32 →	+5.247	+4.429	.005	.005	1	3
BLOOD_Leukemia	GTPBP1 →	+4.736	+5.560	.003	.003	1	2
BLOOD_Leukemia	GIMAP2 →	+5.321	+5.894	.002	.002	1	2
OVARY	SHB →	+5.415	+5.415	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 836 associations by consensus.

TUBB1 by HYAL1 expression — SKIN

Explore this box plot interactively →