HUWE1

Across TCGA patient cohorts, HUWE1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,524 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HUWE1-associated proteins across cancer lineages are NONO, HMGB3, and XPO1. Each is linked with HUWE1 in more than 5 cancer types. Because this analysis shows association rather than direction, both HUWE1-to-partner and partner-to-HUWE1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HUWE1 versus NONO in UCEC, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HUWE1→partner) and Y-score (partner→HUWE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NONO →	+0.183	+0.600	<.001	<.001	3	6
HNSC	HMGB3 →	+0.712	+0.650	<.001	.001	3	5
HNSC	XPO1 →	+0.282	+0.665	<.001	<.001	3	5
UCEC	THOC5 →	+0.215	+0.681	<.001	<.001	3	5
GBM	THOC6 →	+0.226	+0.277	.002	.002	3	5
HNSC	CPSF2 →	+0.198	+0.603	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,524 associations by consensus.

HUWE1 vs NONO — UCEC

Explore this scatter interactively →