HUWE1

Across TCGA patient cohorts, HUWE1 mutation is significantly associated with the RNA expression of many other genes, with 8,215 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HUWE1-associated genes across cancer lineages are IFI27L1, PBK, and CDCA2. Each is linked with HUWE1 in more than 6 cancer types. Because this analysis shows association rather than direction, both HUWE1-to-partner and partner-to-HUWE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFI27L1 grouped by HUWE1-low versus HUWE1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HUWE1→partner) and Y-score (partner→HUWE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	IFI27L1 →	+0.602	+2.540	<.001	<.001	3	6
COAD	PBK →	+1.065	+2.625	<.001	<.001	2	7
STAD	CDCA2 →	+0.672	+2.247	.002	.001	3	6
COAD	POLE2 →	+0.554	+3.472	<.001	.002	3	5
UCEC	UBE2S →	+0.337	+1.056	.005	<.001	3	5
CESC	IFNG →	+0.801	+1.945	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,215 associations by consensus.

IFI27L1 by HUWE1 expression — STAD

Explore this box plot interactively →