HUWE1

Across TCGA patient cohorts, HUWE1 mutation is significantly associated with the total protein of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HUWE1-associated genes across cancer lineages are eEF2, Rictor_pT1135, and Caspase-7-cleavedD198. Each is linked with HUWE1 in more than 4 cancer types. Because this analysis shows association rather than direction, both HUWE1-to-partner and partner-to-HUWE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by HUWE1-low versus HUWE1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HUWE1→partner) and Y-score (partner→HUWE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.467	+3.584	<.001	.002	3	5
STAD	Rictor_pT1135 →	-0.167	-3.305	.004	.009	3	5
COAD	Caspase-7-cleavedD198 →	+1.487	+2.815	<.001	.001	3	5
COAD	Cyclin-E2 →	+0.266	+3.484	.003	.002	3	5
COAD	ACVRL1 →	-0.272	-3.309	.005	.009	3	4
COAD	PCNA →	+0.400	+3.915	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

eEF2 by HUWE1 expression — COAD

Explore this box plot interactively →