HUWE1

Across TCGA cell cohorts, HUWE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,449 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HUWE1-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Negative regulation of gene expression, epigenetic, and Epigenetic regulation of gene expression. Each is linked with HUWE1 in more than 16 cancer types. Because this analysis shows association rather than direction, both HUWE1-to-partner and partner-to-HUWE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by HUWE1-low versus HUWE1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HUWE1→partner) and Y-score (partner→HUWE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.151	+0.771	<.001	<.001	3	17
BONE	Negative regulation of gene expression, epigenetic →	+0.086	+0.932	<.001	<.001	3	17
BONE	Epigenetic regulation of gene expression →	+0.077	+0.763	<.001	<.001	3	17
STOMACH	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.200	+0.735	<.001	<.001	3	16
BONE	mRNA transport →	+0.112	+0.952	<.001	<.001	3	16
SOFT_TISSUE	RNA export from nucleus →	+0.129	+0.996	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,449 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by HUWE1 expression — BONE

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