HUWE1

Across TCGA cell cohorts, HUWE1 mutation is significantly associated with the RNA expression of many other genes, with 828 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HUWE1-associated genes across cancer lineages are A3GALT2, OR1L3, and TTC19. Each is linked with HUWE1 in more than 3 cancer types. Because this analysis shows association rather than direction, both HUWE1-to-partner and partner-to-HUWE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A3GALT2 grouped by HUWE1-low versus HUWE1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HUWE1→partner) and Y-score (partner→HUWE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	A3GALT2 →	+0.014	+2.343	.005	.006	3	4
SKIN	OR1L3 →	+0.008	+2.415	.001	.009	3	4
LARGE_INTESTINE	TTC19 →	+0.479	+3.169	.005	.006	3	3
BLOOD_Leukemia	BAAT →	+0.078	+2.970	<.001	.001	3	3
BLOOD_Myeloma	NXNL2 →	+0.045	+3.070	<.001	.004	3	2
BLOOD_Lymphoma	NEK11 →	+0.856	+3.321	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 828 associations by consensus.

A3GALT2 by HUWE1 expression — BLOOD_Lymphoma

Explore this box plot interactively →