HUS1

Across TCGA patient cohorts, HUS1 mutation is significantly associated with the RNA expression of many other genes, with 591 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HUS1-associated genes across cancer lineages are TEX101P1, FAM90A24P, and GOLGA6L11P. Each is linked with HUS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both HUS1-to-partner and partner-to-HUS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX101P1 grouped by HUS1-low versus HUS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HUS1→partner) and Y-score (partner→HUS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TEX101P1 →	+0.095	+5.159	.006	.007	3	2
BLCA	FAM90A24P →	+0.078	+5.685	<.001	.003	3	2
BLCA	GOLGA6L11P →	+0.119	+5.411	<.001	.005	3	2
BLCA	FTH1P6 →	+0.471	+6.289	<.001	.001	3	2
BLCA	RNU6-296P →	+0.326	+6.289	<.001	.001	3	2
UCEC	IGHV3OR16-6 →	+0.438	+2.517	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 591 associations by consensus.

TEX101P1 by HUS1 expression — SKCM

Explore this box plot interactively →