HTT-AS

Across TCGA pan-cancer cohorts, HTT-AS RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated HTT-AS data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HTT-AS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HTT-AS expression acts as an unfavorable survival marker, although some lineages such as ESCA and UCS show a favorable association.

KIRC, ESCA, and UCS are the cancer types where HTT-AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	II,III,IV	0.374	0.597	.002	57	view →
ESCA	OS	Quartile	III,IV	0.779	0.434	.007	47	view →
UCS	DFS	Tertile	All	0.880	0.438	.004	36	view →
PAAD	OS	Quartile	II,III,IV	0.772	0.367	.004	19	view →
LGG	DFS	Median	All	0.307	0.542	.001	18	view →
ACC	DFS	Tertile	III,IV	0.965	0.317	.013	15	view →
CESC	DFS	Quartile	II,III,IV	0.559	0.768	.012	12	view →
READ	DFS	Quartile	All	0.884	0.436	.018	9	view →
SKCM	DFS	Quartile	IV	0.099	0.428	.034	9	view →
UVM	OS	Tertile	III,IV	0.302	0.887	.019	8	view →
TGCT	DFS	Tertile	All	0.919	0.793	.038	4	view →
CHOL	DFS	Tertile	All	0.830	0.264	.041	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

HTT-AS–KIRC (DFS)

Open the KIRC breakdown →