HTT-AS

Across TCGA pan-cancer cohorts, HTT-AS RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of HTT-AS’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where HTT-AS RNA is repressed in tumor relative to normal tissue. In most cancer types HTT-AS is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, LUSC, and LUAD are the cancer types where HTT-AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HTT-AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.063	.017	2	view →
LUSC	All	II,III,IV	−0.050	.037	2	view →
LUAD	Male	All	−0.117	.007	1	view →
KICH	All	All	−0.049	.044	1	view →
LIHC	All	All	+0.029	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

HTT-AS–COAD

Open the COAD breakdown →