HTRA4

Across TCGA patient cohorts, HTRA4 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,397 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HTRA4-associated proteins across cancer lineages are PLEK, PLEKHO2_T311, and WAS. Each is linked with HTRA4 in more than 9 cancer types. Because this analysis shows association rather than direction, both HTRA4-to-partner and partner-to-HTRA4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HTRA4 versus PLEK in UCEC, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA4→partner) and Y-score (partner→HTRA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLEK →	+0.653	+0.840	<.001	<.001	3	10
BRCA	PLEKHO2_T311 →	+0.586	+1.114	<.001	<.001	3	10
GBM	WAS →	+0.538	+0.654	<.001	<.001	3	10
OV	ADA2 →	+0.665	+0.784	<.001	<.001	3	10
OV	CORO1A →	+0.609	+0.464	<.001	<.001	3	10
OV	DOCK2 →	+0.652	+0.669	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,397 associations by consensus.

HTRA4 vs PLEK — UCEC

Explore this scatter interactively →