HTRA4

Across TCGA pan-cancer cohorts, HTRA4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated HTRA4 data layer compared with 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HTRA4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated HTRA4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

HNSC, OV, and LUAD are the cancer types where HTRA4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.741	0.510	<.001	76	view →
OV	OS	Tertile	II,III,IV	0.419	0.289	.002	58	view →
LUAD	OS	Median	All	0.859	0.765	.001	52	view →
CESC	OS	Tertile	II,III,IV	0.696	0.323	.003	52	view →
ACC	DFS	Tertile	All	0.200	0.747	.001	46	view →
LGG	DFS	Median	All	0.672	0.799	<.001	40	view →
LIHC	DFS	Quartile	All	0.559	0.336	.006	36	view →
THYM	DFS	Tertile	All	0.845	0.956	.021	22	view →
KIRP	DFS	Median	All	0.976	0.857	.002	21	view →
SCLC	DFS	Median	II,III,IV	0.724	0.458	.008	19	view →
SKCM	OS	Tertile	All	0.437	0.276	.003	18	view →
COAD	OS	Tertile	IV	0.811	0.254	.017	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

HTRA4–HNSC (DFS)

Open the HNSC breakdown →