HTRA4

Across TCGA patient cohorts, HTRA4 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTRA4-associated genes across cancer lineages are STAT3_pY705, FoxM1, and ACC_pS79. Each is linked with HTRA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HTRA4-to-partner and partner-to-HTRA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by HTRA4-low versus HTRA4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA4→partner) and Y-score (partner→HTRA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.298	-2.321	.007	.033	3	2
UCEC	FoxM1 →	+0.314	+3.331	.004	.005	3	1
UCEC	ACC_pS79 →	+0.359	+2.469	.014	.010	3	1
UCEC	IGFBP2 →	-0.650	-2.321	.018	.034	3	1
UCEC	JNK2 →	+0.295	+2.906	<.001	.001	3	1
UCEC	NF2 →	+0.199	+1.700	.030	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

STAT3_pY705 by HTRA4 expression — UCEC

Explore this box plot interactively →