HTRA4

Across TCGA cell cohorts, HTRA4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,368 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible HTRA4-associated GO terms across cancer lineages are Lipoprotein biosynthetic process, Regulation of epithelial cell apoptotic process, and Response to decreased oxygen levels. Each is linked with HTRA4 in more than 5 cancer types. Because this analysis shows association rather than direction, both HTRA4-to-partner and partner-to-HTRA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lipoprotein biosynthetic process grouped by HTRA4-low versus HTRA4-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA4→partner) and Y-score (partner→HTRA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Lipoprotein biosynthetic process →	+0.148	+0.079	<.001	.006	3	6
CNS	Regulation of epithelial cell apoptotic process →	+0.070	+0.033	.001	.002	3	5
URINARY_TRACT	Response to decreased oxygen levels →	+0.052	+0.033	<.001	.002	3	5
SOFT_TISSUE	T cell selection →	+0.075	+0.022	.003	.002	3	5
CNS	Negative regulation of focal adhesion assembly →	+0.052	+0.033	.002	.003	3	4
OESOPHAGUS	Biological process involved in symbiotic interaction →	+0.076	+0.056	.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,368 associations by consensus.

Lipoprotein biosynthetic process by HTRA4 expression — OESOPHAGUS

Explore this box plot interactively →