HTRA4

Across TCGA cell cohorts, HTRA4 mutation is significantly associated with the RNA expression of many other genes, with 250 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HTRA4-associated genes across cancer lineages are FHL5, MBL2, and OR6B3. Each is linked with HTRA4 in more than 1 cancer types. Because this analysis shows association rather than direction, both HTRA4-to-partner and partner-to-HTRA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FHL5 grouped by HTRA4-low versus HTRA4-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA4→partner) and Y-score (partner→HTRA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	FHL5 →	+0.016	+4.807	<.001	.006	3	1
BLOOD_Myeloma	MBL2 →	+0.016	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR6B3 →	+0.020	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CBLN4 →	+0.026	+4.807	<.001	.006	3	1
LARGE_INTESTINE	RNMT →	+0.582	+3.537	.004	.001	3	1
LARGE_INTESTINE	NISCH →	+0.785	+3.082	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 250 associations by consensus.

FHL5 by HTRA4 expression — BLOOD_Myeloma

Explore this box plot interactively →