HTRA3

Across TCGA patient cohorts, HTRA3 mutation is significantly associated with the RNA expression of many other genes, with 2,761 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTRA3-associated genes across cancer lineages are RNA5SP418, RNA5SP86, and PIGPP3. Each is linked with HTRA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HTRA3-to-partner and partner-to-HTRA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP418 grouped by HTRA3-low versus HTRA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA3→partner) and Y-score (partner→HTRA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP418 →	+0.451	+1.785	<.001	.003	3	3
BLCA	RNA5SP86 →	+0.413	+5.229	<.001	.002	3	3
COAD	PIGPP3 →	+0.187	+3.602	<.001	.005	3	3
SKCM	RNU6-1229P →	+0.164	+4.186	<.001	.007	3	3
SKCM	RN7SL311P →	+0.089	+3.513	<.001	.004	3	3
SKCM	RPS12P15 →	+0.122	+2.754	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,761 associations by consensus.

RNA5SP418 by HTRA3 expression — UCEC

Explore this box plot interactively →