HTRA3

Across TCGA pan-cancer cohorts, HTRA3 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated HTRA3 data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher HTRA3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HTRA3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

UVM, ACC, and KIRP are the cancer types where HTRA3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.389	0.855	<.001	156	view →
ACC	DFS	Median	All	0.237	0.656	<.001	100	view →
KIRP	OS	Tertile	All	0.465	0.884	.001	84	view →
LGG	OS	Median	All	0.729	0.888	<.001	53	view →
THCA	OS	Quartile	All	0.964	1.000	.002	46	view →
MESO	OS	Median	All	0.194	0.376	.004	43	view →
UCEC	DFS	Quartile	III,IV	0.843	0.699	.010	30	view →
HNSC	OS	Tertile	All	0.625	0.771	.013	19	view →
STAD	OS	Median	All	0.505	0.656	.001	18	view →
LUAD	OS	Tertile	II,III,IV	0.613	0.347	.005	14	view →
SCLC	OS	Median	II,III,IV	0.462	1.000	.005	13	view →
LIHC	OS	Median	All	0.426	0.707	<.001	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

HTRA3–UVM (OS)

Open the UVM breakdown →