HTRA3

Across TCGA patient cohorts, HTRA3 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTRA3-associated genes across cancer lineages are ATM, Cyclin-E2, and TFRC. Each is linked with HTRA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both HTRA3-to-partner and partner-to-HTRA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by HTRA3-low versus HTRA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA3→partner) and Y-score (partner→HTRA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.496	-1.765	.003	.014	3	3
UCEC	Cyclin-E2 →	+0.169	+2.232	.007	.005	3	3
UCEC	TFRC →	+0.653	+3.700	.001	.001	3	2
UCEC	Caspase-8 →	-0.250	-2.673	.008	.005	3	2
UCEC	EGFR_pY1068 →	-0.220	-1.765	.019	.014	3	1
UCEC	eIF4G →	+0.299	+3.321	.010	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ATM by HTRA3 expression — UCEC

Explore this box plot interactively →