HTRA2

Across TCGA patient cohorts, HTRA2 protein abundance is significantly associated with the RNA expression of many other genes, with 12,466 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HTRA2-associated genes across cancer lineages are ELL2, KLHL31, and TRIM22. Each is linked with HTRA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both HTRA2-to-partner and partner-to-HTRA2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, HTRA2 versus ELL2 in OV, with a Pearson correlation of -0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA2→partner) and Y-score (partner→HTRA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ELL2 →	-0.980	-0.295	<.001	.001	3	4
HNSC	KLHL31 →	+0.716	+0.175	<.001	<.001	3	4
OV	TRIM22 →	-1.175	-0.375	<.001	<.001	3	4
COAD	FKBP11 →	-0.443	-0.174	.002	.001	3	4
LSCC	ZNF514 →	+0.600	+0.352	<.001	<.001	3	4
COAD	GFI1 →	-0.662	-0.198	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,466 associations by consensus.

HTRA2 vs ELL2 — OV

Explore this scatter interactively →