HTRA2

Across TCGA cell cohorts, HTRA2 mutation is significantly associated with the mutation status of many other genes, with 3,176 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible HTRA2-associated genes across cancer lineages are ZNF205, ZBTB46, and LMAN1L. Each is linked with HTRA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both HTRA2-to-partner and partner-to-HTRA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF205 grouped by HTRA2-low versus HTRA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTRA2→partner) and Y-score (partner→HTRA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF205 →	+2.845	+3.209	.003	.003	1	3
BLOOD_Leukemia	ZBTB46 →	+3.845	+3.548	.003	.003	1	3
BLOOD_Leukemia	LMAN1L →	+3.108	+3.108	.008	.008	1	3
BLOOD_Leukemia	KIF2C →	+3.523	+3.662	<.001	<.001	1	3
BLOOD_Leukemia	DGKQ →	+2.997	+3.697	<.001	<.001	1	3
BLOOD_Leukemia	OTOA →	+5.430	+4.157	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,176 associations by consensus.

ZNF205 by HTRA2 expression — BLOOD_Leukemia

Explore this box plot interactively →