HTR7

Across TCGA patient cohorts, HTR7 mutation is significantly associated with the RNA expression of many other genes, with 2,330 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR7-associated genes across cancer lineages are CHEK1, CDY3P, and COQ3. Each is linked with HTR7 in more than 2 cancer types. Because this analysis shows association rather than direction, both HTR7-to-partner and partner-to-HTR7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK1 grouped by HTR7-low versus HTR7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR7→partner) and Y-score (partner→HTR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHEK1 →	+0.557	+2.928	.001	<.001	3	3
HNSC	CDY3P →	+0.028	+5.468	<.001	.002	3	3
UCEC	COQ3 →	+0.384	+1.818	.008	.002	3	3
SKCM	HMBS →	+0.418	+2.446	.004	.001	3	3
COAD	BRI3BP →	+0.509	+3.200	.003	.009	3	2
COAD	GP1BA →	+0.387	+3.342	.009	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,330 associations by consensus.

CHEK1 by HTR7 expression — UCEC

Explore this box plot interactively →