HTR7

Across TCGA cell cohorts, HTR7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,357 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HTR7-associated GO terms across cancer lineages are Adenylate cyclase-activating serotonin receptor signaling pathway, Serotonin receptor signaling pathway, and Regulation of cell-substrate junction assembly. Each is linked with HTR7 in more than 16 cancer types. Because this analysis shows association rather than direction, both HTR7-to-partner and partner-to-HTR7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adenylate cyclase-activating serotonin receptor signaling pathway grouped by HTR7-low versus HTR7-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR7→partner) and Y-score (partner→HTR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Adenylate cyclase-activating serotonin receptor signaling pathway →	-0.218	-0.724	<.001	.001	3	17
BREAST	Serotonin receptor signaling pathway →	-0.236	-0.734	<.001	<.001	3	14
BONE	Regulation of cell-substrate junction assembly →	+0.150	+1.143	<.001	<.001	3	12
BONE	Regulation of cell-matrix adhesion →	+0.144	+1.146	<.001	<.001	3	12
BONE	Regulation of focal adhesion assembly →	+0.150	+1.143	<.001	<.001	3	12
BONE	Establishment of epithelial cell apical/basal polarity →	+0.128	+1.079	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,357 associations by consensus.

Adenylate cyclase-activating serotonin receptor signaling pathway by HTR7 expression — KIDNEY

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