HTR5A

Across TCGA pan-cancer cohorts, HTR5A Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated HTR5A data layer compared with 14 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher HTR5A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated HTR5A expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

THYM, UCS, and ACC are the cancer types where HTR5A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCS	OS	Median	All	0.001	0.690	<.001	36	view →
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
OV	OS	Median	III,IV	0.007	0.837	<.001	24	view →
STAD	OS	Median	IV	0.074	0.496	.002	21	view →
UCEC	DFS	Median	All	0.956	0.626	.013	20	view →
TGCT	OS	Median	All	0.069	0.968	<.001	12	view →
SKCM	DFS	Median	II,III,IV	0.765	0.545	.004	12	view →
LGG	DFS	Median	All	0.110	0.826	<.001	9	view →
PRAD	DFS	Median	All	0.617	0.886	.035	6	view →
LUSC	DFS	Median	III,IV	0.079	0.751	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

HTR5A–THYM (OS)

Open the THYM breakdown →