Across TCGA pan-cancer cohorts, HTR5A-AS1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of HTR5A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HTR5A-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types HTR5A-AS1 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

KIRC are the cancer types where HTR5A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HTR5A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.011	.022	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: HTR5A-AS1 RNA expression & survival · all HTR5A-AS1 data types