HTR3E-AS1

Across TCGA pan-cancer cohorts, HTR3E-AS1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated HTR3E-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher HTR3E-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated HTR3E-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and STAD show a favorable association.

HNSC, ACC, and THCA are the cancer types where HTR3E-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	III,IV	0.869	0.697	.007	63	view →
ACC	DFS	Tertile	All	0.196	0.603	.021	48	view →
THCA	OS	Tertile	III,IV	0.780	0.956	.010	39	view →
READ	DFS	Tertile	III,IV	0.174	0.747	.005	30	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
ESCA	DFS	Tertile	All	0.411	0.591	.006	22	view →
CESC	DFS	Tertile	II,III,IV	0.660	0.812	.010	18	view →
KIRC	OS	Tertile	All	0.537	0.662	.019	18	view →
GBM	OS	Tertile	All	0.248	0.426	.036	9	view →
SKCM	OS	Tertile	IV	0.179	0.727	<.001	9	view →
PAAD	OS	Tertile	All	0.435	0.619	.027	9	view →
LIHC	DFS	Tertile	II,III,IV	0.126	0.469	.029	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

HTR3E-AS1–HNSC (OS)

Open the HNSC breakdown →