Across TCGA pan-cancer cohorts, HTR3D Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated HTR3D data layer compared with 10 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher HTR3D Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated HTR3D expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, ESCA, and LUAD are the cancer types where HTR3D Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.487	.037	12	view →
ESCA	OS	Median	All	0.141	0.700	.001	9	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: HTR3D tumor-vs-normal RNA expression · all HTR3D data types