Across TCGA pan-cancer cohorts, HTR3D RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of HTR3D’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where HTR3D RNA is repressed in tumor relative to normal tissue. In most cancer types HTR3D is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and BRCA are the cancer types where HTR3D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in HTR3D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.166	<.001	9	view →
KICH	All	All	−0.279	<.001	6	view →
BRCA	Female	All	−0.007	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: HTR3D RNA expression & survival · all HTR3D data types