Across TCGA patient cohorts, HTR3D mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR3D-associated genes across cancer lineages are GAPDH, mTOR_pS2448, and PDCD4. Each is linked with HTR3D in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR3D-to-partner and partner-to-HTR3D results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3D→partner) and Y-score (partner→HTR3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.529	+2.321	.016	.034	3	2
UCEC	mTOR_pS2448 →	-0.163	-2.102	.008	.016	3	2
UCEC	PDCD4 →	-0.737	-3.459	<.001	.005	3	2
UCEC	eEF2 →	+0.432	+3.321	.003	.009	3	1
UCEC	EGFR_pY1068 →	-0.309	-2.321	.002	.006	3	1
UCEC	A-Raf_pS299 →	-0.101	-2.321	.041	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Exploration

HTR3D survival (RNA) · tumor vs normal (RNA) · all HTR3D data types