Across TCGA cell cohorts, HTR3D RNA expression is significantly associated with the mutation status of many other genes, with 223 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible HTR3D-associated genes across cancer lineages are CCDC40, ZSCAN1, and HSDL1. Each is linked with HTR3D in more than 1 cancer types. Because this analysis shows association rather than direction, both HTR3D-to-partner and partner-to-HTR3D results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3D→partner) and Y-score (partner→HTR3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CCDC40 →	+4.807	+0.020	.006	<.001	3	2
SKIN	ZSCAN1 →	+4.022	+0.010	.006	<.001	3	2
BLOOD_Leukemia	HSDL1 →	+5.539	+0.019	.003	<.001	3	2
BLOOD_Leukemia	IGSF10 →	+2.802	+0.006	.007	<.001	3	2
BLOOD_Leukemia	ASTE1 →	+4.539	+0.014	.007	<.001	3	2
BLOOD_Leukemia	SMG8 →	+5.539	+0.019	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 223 associations by consensus.

Exploration

HTR3D survival (RNA) · tumor vs normal (RNA) · all HTR3D data types