HTR3C2P

Across TCGA pan-cancer cohorts, HTR3C2P RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated HTR3C2P data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher HTR3C2P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated HTR3C2P expression acts as an unfavorable survival marker, although some lineages such as LAML and BRCA show a favorable association.

KIRC, MESO, and THCA are the cancer types where HTR3C2P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.526	0.672	<.001	111	view →
MESO	DFS	Tertile	All	0.217	0.380	.022	54	view →
THCA	DFS	Tertile	III,IV	0.429	0.754	.001	40	view →
PAAD	DFS	Tertile	III,IV	0.118	0.734	.014	36	view →
LAML	DFS	Tertile	All	0.559	0.202	.001	34	view →
LUAD	OS	Tertile	III,IV	0.494	0.699	.006	33	view →
ESCA	OS	Quartile	IV	0.220	0.767	.017	12	view →
BRCA	DFS	Tertile	III,IV	0.957	0.853	.032	12	view →
UVM	DFS	Tertile	III,IV	0.129	0.673	.017	9	view →
LGG	OS	Quartile	All	0.738	0.475	.018	9	view →
DLBC	DFS	Tertile	III,IV	0.137	0.761	.014	9	view →
CESC	OS	Tertile	All	0.879	0.764	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

HTR3C2P–KIRC (DFS)

Open the KIRC breakdown →