HTR3B

Across TCGA patient cohorts, HTR3B mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR3B-associated genes across cancer lineages are Caspase-7-cleavedD198, PDCD4, and XRCC1. Each is linked with HTR3B in more than 3 cancer types. Because this analysis shows association rather than direction, both HTR3B-to-partner and partner-to-HTR3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by HTR3B-low versus HTR3B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3B→partner) and Y-score (partner→HTR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Caspase-7-cleavedD198 →	+0.700	+3.016	.004	.019	3	4
UCEC	PDCD4 →	-0.621	-2.584	.004	.011	3	3
LUAD	XRCC1 →	+0.203	+2.832	.012	.034	3	2
SKCM	ASNS →	+0.408	+2.115	.030	.018	2	3
UCEC	C-Raf →	+0.224	+2.584	<.001	.011	3	2
UCEC	STAT3_pY705 →	-0.461	-3.459	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by HTR3B expression — LUAD

Explore this box plot interactively →