HTR3B

Across TCGA cell cohorts, HTR3B RNA expression is significantly associated with the go_rna of many other GO terms, with 1,596 significant associations in total. BONE shows the largest number of these associations.

The most reproducible HTR3B-associated GO terms across cancer lineages are Lung development, Negative regulation of cell fate commitment, and Serotonin-gated cation-selective signaling pathway. Each is linked with HTR3B in more than 3 cancer types. Because this analysis shows association rather than direction, both HTR3B-to-partner and partner-to-HTR3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lung development grouped by HTR3B-low versus HTR3B-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3B→partner) and Y-score (partner→HTR3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Lung development →	-0.141	-0.236	<.001	.002	3	4
SKIN	Negative regulation of cell fate commitment →	-0.148	-0.280	.001	.004	3	3
BONE	Serotonin-gated cation-selective signaling pathway →	+0.187	+0.370	<.001	<.001	3	3
SKIN	Angiogenesis →	-0.045	-0.216	<.001	.001	3	3
SKIN	Regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway →	-0.962	-0.232	<.001	<.001	3	3
SKIN	Regulation of cell chemotaxis to fibroblast growth factor →	-0.677	-0.294	.004	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,596 associations by consensus.

Lung development by HTR3B expression — BONE

Explore this box plot interactively →