HTR3A

Across TCGA patient cohorts, HTR3A mutation is significantly associated with the RNA expression of many other genes, with 4,802 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HTR3A-associated genes across cancer lineages are GSTM2, FAM66C, and RNU6-135P. Each is linked with HTR3A in more than 2 cancer types. Because this analysis shows association rather than direction, both HTR3A-to-partner and partner-to-HTR3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSTM2 grouped by HTR3A-low versus HTR3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HTR3A→partner) and Y-score (partner→HTR3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSTM2 →	-0.561	-2.785	.002	.003	3	3
UCEC	FAM66C →	-0.290	-2.591	<.001	<.001	3	3
LUSC	RNU6-135P →	+0.274	+2.676	.001	.002	3	3
UCEC	CCM2L →	-0.406	-2.874	.002	.001	3	3
UCEC	IER3IP1 →	+0.372	+1.527	.003	.004	3	3
UCEC	KLHL3 →	-0.549	-2.289	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,802 associations by consensus.

GSTM2 by HTR3A expression — UCEC

Explore this box plot interactively →